Related Experiment Video

Updated: Feb 14, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

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The PI3Kα Inhibitor Alpelisib Has Activity in PIK3CA-altered Tumors

    Cancer Discovery
    |February 18, 2018
    PubMed

    Insights

    The PI3Kα inhibitor alpelisib demonstrated a 58.2% disease control rate in solid tumors with PIK3CA alterations. This finding highlights alpelisib

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Background:

    • Solid tumors frequently harbor PIK3CA alterations.
    • PI3Kα is a key driver in various cancers.
    • Targeting PI3Kα offers a potential therapeutic strategy.

    Discussion:

    • Alpelisib targets the PI3Kα pathway.
    • The study evaluated alpelisib in PIK3CA-altered solid tumors.
    • Disease control rate (DCR) is a measure of treatment efficacy.

    Key Insights:

    • Alpelisib achieved a 58.2% DCR in this patient cohort.
    • This indicates significant clinical activity of alpelisib.
    • PIK3CA alteration status is a predictive biomarker.

    Outlook:

    • Further investigation of alpelisib in specific solid tumor types is warranted.
    • Combination therapies may enhance efficacy.
    • Alpelisib represents a promising targeted therapy for PIK3CA-mutated cancers.

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