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Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants

Timothy J B Ulrich1, Taylor P Hansen2, Kimberly J Reid3

  • 1Department of pediatrics, Children's Mercy Hospital, Kansas City, MO, USA. timothyulrich@gmail.com.

Journal of Perinatology : Official Journal of the California Perinatal Association
|February 18, 2018
PubMed

Insights

Post-ligation cardiac syndrome (PLCS) after patent ductus arteriosus (PDA) ligation increases the risk of severe pulmonary morbidity in neonates. However, PLCS does not appear to be associated with severe retinopathy of prematurity (ROP).

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Pulmonary Medicine

Background:

  • Patent ductus arteriosus (PDA) is a common condition in premature infants.
  • Surgical ligation is a treatment option for PDA.
  • Post-ligation cardiac syndrome (PLCS) is a potential complication of PDA ligation, but its impact on neonatal outcomes is not well understood.

Purpose of the Study:

  • To investigate the association between PLCS and severe neonatal pulmonary morbidity.
  • To determine the risk of PLCS in relation to severe retinopathy of prematurity (ROP).

Main Methods:

  • Retrospective cohort study of 100 infants undergoing PDA ligation between 2006 and 2015.
  • Comparison of outcomes between neonates with and without PLCS.
  • Primary outcome: severe bronchopulmonary dysplasia (BPD). Secondary outcomes: home oxygen therapy and severe ROP.

Main Results:

  • 31% of neonates developed PLCS.
  • PLCS was associated with an increased risk of severe BPD (RR 1.67) and home oxygen therapy (RR 1.47).
  • No significant association was found between PLCS and severe ROP (RR 1.48).

Conclusions:

  • PLCS is linked to increased severe pulmonary morbidity in neonates following PDA ligation.
  • PLCS is not associated with severe retinopathy of prematurity.
  • Further research is recommended to confirm these findings.
Abstract

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