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Basal Cell Carcinoma in Cases with or without Xeroderma Pigmentosum
Dilasma Ghartimagar1, Arnab Ghosh1, Sushil Ram Shrestha2
1Department of Pathology, Manipal College of Medical Science, Pokhara, Nepal.
JNMA; Journal of the Nepal Medical Association
|February 18, 2018
Summary
Basal cell carcinoma (BCC) most commonly presents as nodular or pigmented subtypes, predominantly on the head and neck. Patients with Xeroderma Pigmentosum develop BCC at a younger age with multiple lesions.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Basal cell carcinoma (BCC) is the most prevalent human cancer, primarily affecting fair-skinned individuals with a rising incidence.
- Understanding BCC epidemiology, topography, and histological subtypes is crucial for effective management.
Purpose of the Study:
- To investigate the epidemiology, anatomical distribution (topography), and histological variations of basal cell carcinoma.
- To compare BCC characteristics in patients with and without Xeroderma Pigmentosum.
Main Methods:
- A cross-sectional descriptive study was conducted.
- Data was collected from 77 individuals (91 biopsies) diagnosed with basal cell carcinoma between January 2009 and December 2016.
- Included patients with and without Xeroderma Pigmentosum.
Main Results:
- Nodular (53.94%) and pigmented (18.42%) were the most common BCC subtypes.
- The head and neck region, particularly the nasal and orbital areas, showed the highest incidence.
- BCC occurred in younger individuals with Xeroderma Pigmentosum, often presenting as multiple lesions.
Conclusions:
- Nodular and pigmented subtypes are most frequent, with the nose being the most common site.
- Basal cell carcinoma in Xeroderma Pigmentosum patients typically manifests at a younger age and as multiple lesions.
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