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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.9K

How do physical capacity, fatigue and performance differ in children with duchenne muscular dystrophy compared with

Akmer Mutlu1, Halil Alkan, Tuzun Fırat

  • 1Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.

Neurosciences (Riyadh, Saudi Arabia)
|February 19, 2018
PubMed

Insights

Children with Duchenne Muscular Dystrophy (DMD) experience greater fatigue and energy expenditure than healthy peers. These differences are more pronounced in individuals with lower functional mobility.

Area of Science:

  • Pediatric Neuromuscular Diseases
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Duchenne Muscular Dystrophy (DMD) significantly impacts children's functional abilities and daily activities.
  • Understanding energy expenditure and fatigue is crucial for managing DMD progression and quality of life.

Purpose of the Study:

  • To compare fatigue levels and energy expenditure in children with Duchenne Muscular Dystrophy (DMD) across different functional levels.
  • To compare these metrics against those of healthy children.

Main Methods:

  • A cross-sectional study involving 52 children with DMD (Brooke Functional Classification Scale Levels I-III) and 17 healthy children.
  • Utilized the Six Minute Walk Test (6MWT), Northstar Ambulatory Assessment Scale (NSAA), Physiological Cost Index (PCI), and timed performance tests.

Main Results:

  • Significant differences in Physiological Cost Index (PCI) were observed between DMD functional Levels 2 and 3, and Levels 1 and 3 (p<0.0083).
  • Fatigue after activity, assessed by stair climbing post-6MWT, showed significant differences.

Conclusions:

  • Children with DMD exhibited higher walking distances, fatigue levels, and energy expenditure compared to healthy children.
  • These differences were more pronounced as the functional level of DMD patients decreased.
Abstract

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