Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Diltiazem in chronic stable angina].

J A González-Hermosillo, A C Clemente, E Salazar

    Archivos Del Instituto De Cardiologia De Mexico
    |July 1, 1986
    PubMed
    Summary

    Diltiazem effectively reduced angina frequency and improved exercise capacity in patients with chronic stable angina. This study demonstrates diltiazem

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prevalence of acquired resistance to antiretrovirals in children and adolescents living with HIV under clinical follow-up at the Roosevelt Hospital in Guatemala.

    Journal of infection and public health·2025
    Same author

    Rostered routine testing for severe acute respiratory coronavirus virus 2 infection among healthcare workers: Do we detect more?

    Journal of gastroenterology and hepatology·2021
    Same author

    Bioactivity of hydrolysates obtained from bovine casein using artichoke (Cynara scolymus L.) proteases.

    Journal of dairy science·2019
    Same author

    The Wnt1 ligand/Frizzled 3 receptor system plays a regulatory role in the achievement of the 'in vitro' capacitation and subsequent 'in vitro' acrosome exocytosis of porcine spermatozoa.

    Andrology·2015
    Same author

    Small ruminant lentivirus-induced arthritis: clinicopathologic findings in sheep infected by a highly replicative SRLV B2 genotype.

    Veterinary pathology·2014
    Same author

    Brassica carinata resynthesized by protoplast fusion.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Chronic stable angina is a common manifestation of ischemic heart disease.
    • Current treatments aim to improve symptoms and exercise tolerance.

    Purpose of the Study:

    • To evaluate the safety and efficacy of diltiazem in patients with chronic stable angina.
    • To determine the dose-response relationship of diltiazem on angina frequency and exercise capacity.

    Main Methods:

    • A single-blind, dose-escalation study was conducted in 10 patients with documented ischemic heart disease.
    • Patients received diltiazem at doses of 120, 240, and 360 mg/day.
    • A double-blind, randomized crossover phase further assessed the effects of 360 mg/day diltiazem.

    Main Results:

    • Diltiazem significantly reduced weekly angina frequency in a dose-dependent manner.
    • Exercise duration and time to 1 mm ST depression during exercise were significantly increased with diltiazem.
    • The time to onset of ischemia during exercise was prolonged with 360 mg/day diltiazem compared to placebo.

    Conclusions:

    • Diltiazem, at doses ranging from 120 to 360 mg/day, is an effective antianginal agent.
    • The drug demonstrated a favorable safety profile with no significant adverse effects observed.
    • Diltiazem improves exercise capacity and reduces ischemic events in patients with chronic stable angina.

    Related Experiment Videos