Related Experiment Video
Updated: Feb 14, 2026
11:18
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
8.3K
DDR1: A major player in renal diseases
Aude Dorison1, Christos Chantziantoniou1
1a Inserm UMR S 1155 and Sorbonne Université , Paris , France.
Cell Adhesion & Migration
|February 20, 2018
Summary
Discoidin Domain Receptor 1 (DDR1) drives kidney inflammation and fibrosis in chronic kidney diseases (CKD). Blocking DDR1 shows therapeutic promise in preclinical models, highlighting its potential as a drug target.
Area of Science:
- Nephrology
- Molecular Biology
- Biochemistry
Background:
- Discoidin Domain Receptor 1 (DDR1) is a non-integrin collagen receptor with tyrosine kinase activity.
- DDR1 is implicated in various pathologies, including chronic kidney diseases (CKD).
Purpose of the Study:
- Review DDR1 expression in healthy and diseased kidneys.
- Comment on DDR1's role in CKD pathogenesis.
- Suggest future research directions for DDR1 signaling in CKD.
Main Methods:
- Literature review and commentary on existing data.
- Analysis of DDR1's involvement in inflammatory and fibrotic pathways.
- Evaluation of therapeutic potential based on preclinical models.
Main Results:
- DDR1 expression is altered in diseased kidneys.
- DDR1 significantly contributes to pro-inflammatory and pro-fibrotic processes in CKD.
- Blockade of DDR1 demonstrates beneficial effects in preclinical CKD models.
Conclusions:
- DDR1 is a key mediator in the development of CKD.
- Targeting DDR1 represents a promising therapeutic strategy for managing CKD.
Related Concept Videos
01:25Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
2
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
2
01:27Major Hormones and Their Functions
2.0K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
2.0K
01:28Major Losses in Pipes
2.0K
When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
2.0K
01:19Major Organs of the Digestive System
10.1K
The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:
Gastrointestinal tract:
10.1K
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
233
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
233
01:17Factors Affecting Renal Clearance: Renal Impairment
485
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
485