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Neurocognitive disorder in hypertensive patients. Heart-Brain Study
A Vicario1, G H Cerezo2, M Del Sueldo3
1Heart-Brain Unit, Cardiovascular Institute of Buenos Aires (ICBA), Argentina.
Hipertension Y Riesgo Vascular
|February 20, 2018
Summary
Hypertension significantly impacts cognitive function, with executive dysfunction and semantic memory being most affected. High blood pressure and pulse pressure are linked to cognitive decline in hypertensive individuals.
Area of Science:
- Neurology
- Cardiology
- Gerontology
Background:
- Hypertension is a known risk factor for cognitive impairment.
- Understanding the specific cognitive domains affected and associated risk factors is crucial for early intervention.
Purpose of the Study:
- To determine the prevalence of cognitive impairment in hypertensive patients.
- To identify the most affected cognitive domains.
- To explore associations between cognitive impairment and hypertension parameters/vascular risk factors.
Main Methods:
- A multicentre study included 1281 hypertensive patients (≥21 years).
- Data collected: cognitive status (Minimal Cognitive Examination), behavioral status (Hospital Anxiety and Depression Scale), blood pressure, anthropometry, biochemical profile.
- Statistical analysis was performed to identify significant associations.
Main Results:
- Global cognitive impairment observed in 22.1% of patients.
- Executive dysfunction (36.2%) and semantic memory impairment (48.9%) were most prevalent.
- Higher cognitive impairment rates in males and older age groups.
- High pulse pressure correlated with abnormal Clock Drawing Test results.
- High systolic blood pressure and pulse pressure linked to abnormal Mini-Boston Naming Test results.
- Treated/uncontrolled hypertension associated with poorer performance on cognitive tests.
Conclusions:
- Cognitive impairment is more common in hypertensive patients than in the general population.
- Executive functions and semantic memory are particularly vulnerable.
- Elevated systolic blood pressure and pulse pressure are significant risk factors for cognitive deficits in hypertension.
Keywords:
Cognitive impairmentDeterioro cognitivoDisfunción ejecutivaExecutive dysfunctionFactores de riesgo vascularHipertensiónHypertensionMemoria semánticaSemantic memoryVascular risk factorsMore Related Videos
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