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Updated: Aug 12, 2026
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Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations
Published on: June 17, 2011
Hippocampal long-term potentiation increases mitochondrial calcium pump activity in rat
Brain Research
|September 10, 1986
Abstract:
45Ca2+ pump activity was measured in hippocampal homogenates after the induction of long-term potentiation (LTP) of perforant path-dentate gyrus synapses in vivo. The mitochondrial poison, sodium azide, was used to separate mitochondrial from non-mitochondrial 45Ca2+ uptake. High-frequency stimulation of the perforant path input produced a selectively increased mitochondrial uptake of calcium. This increased pump activity may permit granule cells to more effectively buffer higher intracellular calcium levels associated with LTP.
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01:35Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...