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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Primary Lymphoid Organs01:16

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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The lymphoid cell network in the skin.

Shweta Tikoo1,2, Rohit Jain1,2, Angela Rm Kurz1

  • 1The Centenary Institute, Newtown, NSW, 2042, Australia.

Immunology and Cell Biology
|February 20, 2018
PubMed
Summary

Cutaneous immunity relies on specialized immune cells in the skin to balance tolerance and activation. This review highlights recent advances in understanding cutaneous lymphoid biology and its role in skin health.

Keywords:
Gamma delta T cellsinnate lymphoid cellsregulatory T cellstissue-resident memory T cells

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • The skin's immune system, or cutaneous immunity, is vital for mammalian defense.
  • Constant surveillance is needed due to commensal microbes and environmental factors.
  • Strategic immune cell placement balances immune tolerance and activation for homeostasis.

Purpose of the Study:

  • To review recent advancements in cutaneous lymphoid biology.
  • To emphasize the role of lymphoid cells in skin health and disease.

Main Methods:

  • Literature review of recent research in cutaneous immunology.
  • Focus on the spatiotemporal coordination of immune cell functions.
  • Analysis of how innate and adaptive immune cells respond to microenvironmental cues.

Main Results:

  • Lymphoid cells play increasingly recognized roles in skin homeostasis.
  • Understanding immune cell interactions is key to modulating skin responses.
  • Recent research has shed light on the complex mechanisms of cutaneous immunity.

Conclusions:

  • Cutaneous immunity is a dynamic field with significant implications for skin health.
  • Further research into cutaneous lymphoid biology is crucial for understanding and treating skin pathologies.
  • The coordinated actions of immune cells are central to maintaining skin integrity.