Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

747
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
747
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.1K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.1K
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

610
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
610
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

1.3K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.3K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

703
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
703
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

896
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
896

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thalassaemia.

Nature reviews. Disease primers·2026
Same author

EIF2AK1 As a Key Genetic Determinant of Luspatercept Resistance in Transfusion-Dependent Thalassemia.

American journal of hematology·2026
Same author

Targeting ineffective erythropoiesis in thalassemia: biologic therapies and emerging therapeutic strategies.

Expert opinion on biological therapy·2026
Same author

Addressing Obstetric and Gynecologic Needs in Thalassemia.

O&G open·2026
Same author

The Lebanese national patient blood management guidelines: A new page in the medical practice.

Blood reviews·2026
Same author

EHA Recommendations for preconceptual and antenatal screening and prenatal diagnosis for hemoglobinopathies.

HemaSphere·2026

Related Experiment Video

Updated: Feb 14, 2026

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

1.8K

Clinical Complications and Their Management.

Alessia Marcon1, Irene Motta2, Ali T Taher3

  • 1Department of Medicine, Cà Granda Foundation IRCCS, Via Francesco Sforza 35, Milano 20122, Italy; Department of Clinical Science and Community, University of Milan, Via Francesco Sforza 35, Milano 20122, Italy.

Hematology/Oncology Clinics of North America
|February 21, 2018
PubMed
Summary

Thalassemias cause ineffective red blood cell production and breakdown, leading to complications. This review details common issues in transfusion-dependent (TDT) and non-transfusion-dependent (NTDT) thalassemia and their management.

Keywords:
EndocrinopathiesHeart failureIneffective erythropoiesisIron overloadLiver diseaseThalassemia

More Related Videos

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion
05:30

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion

Published on: February 14, 2025

1.6K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Related Experiment Videos

Last Updated: Feb 14, 2026

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

1.8K
Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion
05:30

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion

Published on: February 14, 2025

1.6K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Thalassemias are inherited blood disorders characterized by reduced hemoglobin production.
  • Key pathophysiological features include ineffective erythropoiesis and peripheral hemolysis.
  • These mechanisms contribute to a wide range of clinical complications.

Purpose of the Study:

  • To review the most common clinical complications in transfusion-dependent (TDT) and non-transfusion-dependent (NTDT) thalassemia.
  • To discuss the management strategies for these complications.
  • To highlight shared and distinct complications between TDT and NTDT phenotypes.

Main Methods:

  • Literature review of clinical complications in TDT and NTDT.
  • Synthesis of current management approaches for identified complications.
  • Comparative analysis of complication prevalence between TDT and NTDT groups.

Main Results:

  • Both TDT and NTDT thalassemias present with significant clinical complications throughout life.
  • Certain complications are common to both groups, while others show higher prevalence in either TDT or NTDT.
  • Effective management strategies are crucial for improving patient outcomes.

Conclusions:

  • Understanding the spectrum of clinical complications in thalassemia is essential for comprehensive patient care.
  • Tailored management approaches are necessary for TDT and NTDT patients.
  • Further research into novel therapeutic strategies is warranted.