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Clinical Complications and Their Management

Alessia Marcon1, Irene Motta2, Ali T Taher3

  • 1Department of Medicine, Cà Granda Foundation IRCCS, Via Francesco Sforza 35, Milano 20122, Italy; Department of Clinical Science and Community, University of Milan, Via Francesco Sforza 35, Milano 20122, Italy.

Hematology/Oncology Clinics of North America
|February 21, 2018
PubMed

The hallmarks of thalassemias are ineffective erythropoiesis and peripheral hemolysis leading to a cascade of events responsible for several clinical complications. This pathophysiologic mechanism can be partially controlled by blood transfusions or by correction of the severity of ineffective erythropoiesis. Thalassemias include a spectrum of phenotypes. Two main groups can be clinically distinguished: transfusion-dependent (TDT) and non-transfusion-dependent (NTDT) thalassemia. Both conditions are characterized by several clinical complications along life; some are shared, whereas some have higher prevalence in one group over the other. The authors present the most common clinical complications in TDT and NTDT and their management.

Keywords:
EndocrinopathiesHeart failureIneffective erythropoiesisIron overloadLiver diseaseThalassemia

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