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A planar impedance sensor for 3D spheroids.

V F Curto1, M P Ferro, F Mariani

  • 1Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 880 Avenue de Mimet, Gardanne 13541, France.

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Summary
This summary is machine-generated.

Researchers developed a novel platform using organic electrochemical transistors to measure the electrical impedance of 3D spheroids, advancing drug screening and tissue engineering models.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cell Biology

Background:

  • Three-dimensional (3D) cell cultures, such as spheroids, are crucial for mimicking native tissue microenvironments in drug testing and tissue engineering.
  • High-throughput technologies enable reproducible spheroid generation for in vitro models, but require effective monitoring platforms.
  • Existing drug screening platforms lack integrated monitoring capabilities for 3D spheroid models.

Purpose of the Study:

  • To present a novel platform for measuring the electrical impedance of 3D spheroids.
  • To overcome fabrication challenges in integrating microdevices with organic electrochemical transistors (OECTs).
  • To validate the platform's capability in assessing spheroid characteristics and real-time monitoring.

Main Methods:

  • Development of a novel impedance measurement platform utilizing a planar organic electrochemical transistor (OECT).
  • Integration of a circular-shaped microtrap with the OECT for spheroid analysis.
  • Implementation of a new strategy to resolve polydimethylsiloxane (PDMS) microdevice and OECT fabrication incompatibility.
  • Testing the platform with mono- and co-cultures of fibroblast and epithelial spheroids.

Main Results:

  • Successful measurement of spheroid resistance (Rsph) in 3D spheroids.
  • Demonstrated correlation between measured Rsph and spheroid ion permeability.
  • Validated the platform's potential for on-line Rsph monitoring during exposure to a porogenic agent affecting cell membrane integrity.

Conclusions:

  • The developed OECT-based platform offers a novel method for assessing 3D spheroid electrical impedance.
  • The platform can differentiate spheroids based on ion permeability and monitor real-time changes in spheroid integrity.
  • This technology holds promise for advancing in vitro drug screening and tissue engineering applications.