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Decanethiol functionalized silver nanoparticles are new powerful leishmanicidals in vitro
A P Isaac-Márquez1, P Talamás-Rohana2, N Galindo-Sevilla3
1Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Av. Patricio Trueba de Regil s/n, Col. Lindavista, C.P. 24090, San Francisco de Campeche, Camp, Mexico. anpisaac@hotmail.com.
World Journal of Microbiology & Biotechnology
|February 21, 2018
Summary
Decanethiol functionalized silver nanoparticles (AgNps-SCH) show significant leishmanicidal activity against various Leishmania strains. These nanoparticles offer a potent, non-toxic alternative treatment for leishmaniasis with a high therapeutic index.
Area of Science:
- Nanotechnology
- Parasitology
- Infectious Diseases
Background:
- Leishmaniasis is a neglected tropical disease treated with sodium stibogluconate (Sb), which has limitations.
- Novel therapeutic strategies are needed to combat Leishmania parasites effectively.
Purpose of the Study:
- To evaluate the leishmanicidal potential of decanethiol functionalized silver nanoparticles (AgNps-SCH).
- To compare the efficacy and safety of AgNps-SCH with sodium stibogluconate (Sb).
Main Methods:
- Assessed AgNps-SCH activity against promastigotes and amastigotes of Leishmania mexicana and Leishmania major.
- Measured parasite growth kinetics, mobility, proliferation, and killing.
- Determined IC50 values, therapeutic index, and cytotoxicity in macrophages.
Main Results:
- AgNps-SCH demonstrated remarkable leishmanicidal effects at concentrations 10,000 times lower than Sb.
- No toxicity was observed in J774A.1 macrophages at effective concentrations (>85% viability).
- AgNps-SCH exhibited a therapeutic index approximately 20,000-fold greater than Sb and inhibited >80% parasite proliferation.
Conclusions:
- AgNps-SCH possess high leishmanicidal potential at 0.04 µM concentrations.
- AgNps-SCH represent a promising alternative treatment for leishmaniasis.
- Further in vivo studies are warranted to validate AgNps-SCH efficacy for different leishmaniasis types.
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