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Published on: December 14, 2014
Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation
Kristen P Morie1,2, Jia Wu1,2, Nicole Landi2,3
1a Department of Psychiatry , Yale University School of Medicine , New Haven , CT , USA.
Abstract:
Impaired cognitive control is a consequence of cocaine exposure. Difficulty with feedback processing may underlie this impairment. We examined neural correlates of feedback processing using event-related potentials (ERPs) in 49 prenatally cocaine-exposed (PCE) and 34 nondrug exposed (NDE) adolescents. Adolescents performed a reward-feedback task with win/no-win feedback in a chance-based task. We investigated amplitude and latency of the feedback-related negativity (FRN) and P300 ERP components and source-based estimates elicited during feedback processing. PCE adolescents had smaller P300 amplitudes for no-win feedback, and source analysis in the P300 time window revealed differences between groups localized to the dorsal anterior cingulate cortex.
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