[RESTORATION OF SYMPATHO-PARASYMPATHETIC BALANCE IN HEART RATE VARIABILITY IN THE DEVELOPMENT OF PSYCHOEMOTIONAL...

Area of Science:

• Cardiovascular physiology
• Neuroscience
• Pharmacology

Background:

• Prolonged immobilization induces psychoemotional stress, leading to sympatho-parasympathetic imbalance.
• Heart rate variability (HRV) analysis reveals stress-induced autonomic nervous system dysregulation.
• Taurine's role in adaptive processes and its effects on stress recovery are not fully understood.

Purpose of the Study:

• To investigate the impact of taurine on HRV during immobilization stress.
• To evaluate taurine's efficacy in restoring sympatho-parasympathetic balance post-stress.
• To determine the optimal timing for taurine intervention in early post-stress adaptation.

Main Methods:

• Spectral analysis of heart rate variability (HRV) in rats subjected to 5-hour immobilization.
• Assessment of low-frequency (LF) and high-frequency (HF) components of HRV.
• Daily intraperitoneal taurine administration (50 mg/kg) before and after immobilization.
• Scatterogram analysis of heart rate regression to assess cardiovascular effects.

Main Results:

• Immobilization stress significantly altered HRV, decreasing total power and HF components while increasing LF and VLF components.
• Taurine administration mitigated stress effects, promoting a shift towards sympathovagal balance restoration.
• Complete vago-sympathetic balance recovery was observed by day 7 post-immobilization with daily taurine treatment.
• Taurine stabilized heart rate variability, indicating a beneficial cardiovascular effect.

Conclusions:

• Taurine effectively accelerates adaptive processes in the early post-stress period.
• Early intervention with taurine is crucial for preventing stress-induced cardiovascular pathology.
• Taurine demonstrates significant potential in managing stress-related autonomic dysregulation.