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[Is celecoxib a safe alternative for the Fernand Widal syndrome?]
A Schaller1, C Metz-Favre1, L Guenard-Bilbaut1
1Unité d'allergologie, pôle de pathologie thoracique, Nouvel hôpital civil, 1, place de l'Hôpital, 67000, Strasbourg, France.
Revue Des Maladies Respiratoires
|February 22, 2018
Summary
Fernand Widal syndrome patients may experience bronchospasm with celecoxib, a selective COX-2 inhibitor. Careful medical supervision is crucial when considering this drug for patients with asthma, nasal polyposis, and aspirin sensitivity.
Area of Science:
- Clinical Immunology
- Pharmacology
Background:
- Fernand Widal syndrome involves asthma, nasal polyposis, and aspirin sensitivity.
- Selective cyclooxygenase-2 (COX-2) inhibitors offer an alternative for pain and inflammation management.
Purpose of the Study:
- To evaluate the safety and tolerability of celecoxib in patients with Fernand Widal syndrome.
- To compare celecoxib's effects in Fernand Widal syndrome patients versus controls with NSAID sensitivity.
Main Methods:
- Retrospective study of oral provocation tests (OPT) with celecoxib.
- Eight patients with Fernand Widal syndrome and 27 control patients with NSAID sensitivity were included.
Main Results:
- Four Fernand Widal syndrome patients developed bronchospasm with celecoxib.
- Control patients tolerated celecoxib without adverse reactions.
- Reacting Fernand Widal patients exhibited lower aspirin reactivity thresholds and/or more severe asthma.
Conclusions:
- Celecoxib is not consistently a safe alternative to NSAIDs for Fernand Widal syndrome patients.
- Introduction of celecoxib in these patients requires a hospital setting and medical supervision.
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