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Ocular Biometry in Primary Angle-Closure Glaucoma Associated with Retinitis Pigmentosa
Jiangang Xu1, Zhikun Ouyang1, Yangfan Yang1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Journal of Ophthalmology
|February 22, 2018
Summary
Retinitis pigmentosa (RP) and primary angle-closure glaucoma (PACG) share similar ocular biometric characteristics. This suggests that RP is likely coincidental in patients with angle-closure glaucoma, not a direct cause.
Area of Science:
- Ophthalmology
- Genetics
- Biometry
Background:
- Retinitis pigmentosa (RP) is an inherited condition causing progressive vision loss.
- Primary angle-closure glaucoma (PACG) is a condition affecting intraocular pressure and vision.
Purpose of the Study:
- To investigate ocular biometric differences in patients with both PACG and RP.
- To determine if a relationship exists between PACG and RP.
Main Methods:
- Retrospective case-control study.
- Ultrasound biomicroscopy (UBM) and A-scan biometry used to measure anterior chamber depth (ACD), lens thickness (LT), and axial length (AL).
- Propensity score matching and mixed linear regression analysis applied to 583 patients.
Main Results:
- No significant differences in ACD, AL, or relative lens position (RLP) between PACG with RP and PACG alone.
- Patients with acute PACG (APACG) and RP showed significantly greater LT compared to APACG alone.
Conclusions:
- Patients with PACG associated with RP exhibit similar biometric parameters to those with PACG alone.
- The findings suggest a coincidental association between RP and angle-closure glaucoma.
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