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Updated: Feb 14, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Treatment of Pediatric Pulmonary Hypertension
Manish Aggarwal1, R Mark Grady2
1Division of Pediatric Cardiology, Washington University in St. Louis, St. Louis, MO, USA. maggarwal@wustl.edu.
Insights
Pediatric pulmonary hypertension (PH) is rising due to better survival rates in complex conditions. This review covers new PH therapies for children, including the potential benefits of a Potts shunt.
Area of Science:
- Pediatric Cardiology
- Pulmonary Medicine
- Critical Care
Background:
- Pediatric pulmonary hypertension (PH) is increasingly diagnosed in tertiary care settings.
- Improved survival in extreme prematurity and congenital heart disease contributes to higher PH incidence.
- Advances in pharmacologic and interventional treatments for PH are emerging.
Purpose of the Study:
- To review current and recent therapeutic advances for pediatric pulmonary hypertension.
- To highlight the potential role of a Potts shunt in managing severe pediatric PH.
Main Methods:
- Literature review of recent advances in pediatric PH therapies.
- Discussion of expert consensus and clinical experience in treatment.
- Focus on novel and established treatment modalities.
Main Results:
- Most pediatric PH therapies lack rigorous randomized controlled trials.
- Treatment decisions often rely on expert consensus and clinical experience.
- The Potts shunt is presented as a potential intervention for severe pediatric PH.
Conclusions:
- There is a growing need for evidence-based treatments in pediatric PH.
- The Potts shunt may offer a viable option for select pediatric PH cases.
- Continued research and clinical trials are crucial for advancing pediatric PH care.
Abstract:
Pulmonary hypertension (PH) is an increasingly recognized problem in children, particularly within tertiary pediatric hospitals. This increase is, in large part, due to ever improving survival among previously fatal conditions, such as extreme prematurity and complicated congenital heart disease. This increased recognition has paralleled burgeoning pharmacologic and interventional PH-specific treatment options. Unfortunately, most PH-specific therapies have not been tested in children with rigorous, randomized, controlled trials. As a result, most treatment of PH in children is based upon expert consensus and practitioners' experience. In this article, we highlight some of the current and recent advances in therapies available for children with PH. The role that a Potts shunt may have in ameliorating severe PH in children is highlighted.
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