Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Schemas01:42

Schemas

12.4K
A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
12.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD2 targeted nanoparticles containing IL-2 mimic fetal-maternal tolerance of pregnancy by inducing synergistic TGF-β-producing NK cells and Tregs.

Frontiers in immunology·2025
Same author

Editorial: Cholesterol, inflammation and immunity.

Frontiers in immunology·2025
Same author

CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders.

Frontiers in immunology·2025
Same author

B cell immunometabolism in health and disease.

Nature immunology·2025
Same author

MIP-C: A new autoimmune rheumatic disease concomitant with the COVID-19 pandemic.

Rheumatology and immunology research·2024
Same author

CAR immunotherapy in autoimmune diseases: promises and challenges.

Frontiers in immunology·2024
Same journal

Type I Interferonopathies: Fifteen Years On, From Concept to Therapeutic Perspectives.

Current rheumatology reports·2026
Same journal

Intensive Care Management of ANCA-associated Vasculitides: a Narrative Review.

Current rheumatology reports·2026
Same journal

The Role of Musculoskeletal Ultrasound in Psoriatic Arthritis: From Preclinical Detection to Treatment Monitoring.

Current rheumatology reports·2026
Same journal

Correction to: Is Gout and Autoinflammatory Disease?

Current rheumatology reports·2026
Same journal

Risks and Management of Glucocorticoid Therapy for Patients with Rheumatic Disease Having Surgery.

Current rheumatology reports·2026
Same journal

Perioperative Management Considerations for Patients with Systemic Lupus Erythematosus.

Current rheumatology reports·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K

Tregs in SLE: an Update.

Antonio La Cava1

  • 1Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, CA, 90095, USA. alacava@mednet.ucla.edu.

Current Rheumatology Reports
|February 22, 2018
PubMed
Summary
This summary is machine-generated.

Regulatory T cells (Tregs) are crucial for immune balance. This review explores recent findings on Treg dysfunction in systemic lupus erythematosus (SLE) and its therapeutic implications.

Keywords:
SLET regulatory cells

More Related Videos

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.5K
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Related Experiment Videos

Last Updated: Feb 14, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K
Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.5K
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Area of Science:

  • Immunology
  • Autoimmunity
  • Cellular Biology

Background:

  • T regulatory cells (Tregs) play a vital role in maintaining immune homeostasis.
  • Reduced Treg number or function is observed in various autoimmune diseases, including systemic lupus erythematosus (SLE).
  • Despite significant research, the precise mechanisms underlying Treg impairment in SLE remain incompletely understood.

Purpose of the Study:

  • To review recent advancements in understanding the role and dysfunction of Tregs in SLE.
  • To discuss mechanistic studies, preclinical research, and clinical trials related to Tregs in SLE.
  • To highlight progress in the physiopathology of Tregs in SLE over the past five years.

Main Methods:

  • Review of recent scientific literature focusing on Treg function in SLE.
  • Analysis of mechanistic studies investigating cellular and molecular pathways affecting Tregs.
  • Evaluation of preclinical and clinical data from immunotherapeutic studies in lupus patients.

Main Results:

  • Identification of specific cellular and molecular abnormalities contributing to Treg impairment in SLE.
  • Development of animal models to study Treg dysfunction in SLE.
  • Initiation of pilot immunotherapeutic studies targeting Tregs in SLE patients.

Conclusions:

  • Recent research has elucidated key mechanisms behind Treg dysfunction in SLE.
  • Preclinical and clinical studies show promise for Treg-based immunotherapies in SLE.
  • Further investigation is needed to fully understand and leverage Treg function in SLE treatment.