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Changes in D-dimer concentration after soft tissue and orthopedic surgery in dogs
Anna Shipov1, Josh Milgram1, Nitzan Shalev1
1Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 761001, Israel.
Veterinary Surgery : VS
|February 22, 2018
Summary
Surgery generally does not significantly elevate D-dimer levels in dogs. Any increase in D-dimer concentration post-surgery warrants investigation for hemostatic derangements.
Area of Science:
- Veterinary Medicine
- Hematology
- Surgical Science
Background:
- D-dimer is a specific marker indicating active coagulation and fibrinolysis.
- Understanding the impact of surgical procedures on D-dimer levels is crucial for accurate clinical interpretation.
Purpose of the Study:
- To determine the influence of surgical procedures on D-dimer concentration in dogs.
- To correlate the magnitude of D-dimer changes with the invasiveness of surgical procedures.
Main Methods:
- A prospective clinical study involving 45 client-owned dogs.
- Dogs underwent elective neutering, elective orthopedic, or posttraumatic orthopedic surgery.
- D-dimer concentrations were measured immediately before, immediately after, and 24 hours post-surgery.
Main Results:
- No significant difference in the proportion of dogs with elevated D-dimer (>250 ng/mL) was observed across time points.
- Median D-dimer concentrations did not significantly vary between time points, except for a slight trend of increase in the neutering group post-surgery.
- Elevated D-dimer levels (>500 ng/mL) were rare post-surgery.
Conclusions:
- Surgical procedures, including elective and posttraumatic orthopedic surgeries and neutering, are unlikely to cause a substantial direct increase in D-dimer concentration.
- Any post-operative increase in D-dimer should be considered clinically significant and investigated for underlying hemostatic abnormalities.
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