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Peripheral Vasculitic Neuropathy Associated With Minocycline Use
Min K Kang1,2, Rajesh K Gupta1, Jayashri Srinivasan1
1Department of Neurology, Lahey Hospital and Medical Center, Burlington, MA.
Journal of Clinical Neuromuscular Disease
|February 22, 2018
Summary
Minocycline can cause vasculitis leading to multiplex mononeuritis and skin issues. Stopping the drug improved patient symptoms and lab results, even without other autoimmune diseases.
Area of Science:
- Neurology
- Dermatology
- Rheumatology
Background:
- Minocycline is an antibiotic used for various conditions.
- Vasculitis is inflammation of blood vessels.
- Multiplex mononeuritis involves damage to multiple individual nerves.
Observation:
- Two patients presented with multiplex mononeuritis and skin manifestations.
- These symptoms were linked to minocycline-induced vasculitis.
- One case lacked associations with lupus or polyarteritis nodosa.
Findings:
- Extensive tests ruled out other immunologic disorders.
- Electrodiagnostic studies revealed patchy, multifocal axonal neuropathy.
- Nerve biopsy confirmed the diagnosis of multiplex mononeuritis.
Implications:
- Discontinuation of minocycline led to clinical improvement.
- Cessation of the drug also improved quantitative serological measures.
- This highlights minocycline as a potential cause of vasculitis presenting as multiplex mononeuritis.
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