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Related Experiment Videos

Sperm morphologic features as a prognostic factor in in vitro fertilization.

T F Kruger, R Menkveld, F S Stander

    Fertility and Sterility
    |December 1, 1986
    PubMed
    Summary

    Sperm morphology is a key factor in in vitro fertilization (IVF) success. A threshold of 14% normal sperm morphology significantly improves fertilization and pregnancy rates in women undergoing IVF.

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    Area of Science:

    • Reproductive Medicine
    • Andrology
    • In Vitro Fertilization

    Background:

    • Sperm morphology is a crucial parameter in male fertility assessment.
    • Its prognostic value in assisted reproductive technologies like in vitro fertilization (IVF) requires further elucidation.

    Purpose of the Study:

    • To investigate the prognostic significance of the percentage of morphologically normal sperm in human IVF outcomes.
    • To identify a potential threshold for normal sperm morphology predictive of successful IVF.

    Main Methods:

    • A prospective study involving 190 successful laparoscopic cycles in women with bilateral tubal damage.
    • Patients were stratified into four groups based on the percentage of morphologically normal sperm (0-14%, 15-30%, 31-45%, 46-60%).
    • Fertilization rates and pregnancy rates per embryo transfer (ET) were evaluated for each group.

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    Main Results:

    • Group I (0-14% normal morphology) showed no resulting pregnancies despite 37% fertilization.
    • Groups II, III, and IV (≥15% normal morphology) demonstrated significantly higher fertilization rates (81-91%) and pregnancy rates (12-31%).
    • A clear threshold was identified at 14% normal sperm morphology, with superior outcomes observed when this percentage was exceeded.

    Conclusions:

    • The percentage of morphologically normal sperm has significant prognostic value in IVF.
    • A threshold of 14% normal sperm morphology is associated with higher fertilization and pregnancy rates.
    • Sperm morphology assessment is a valuable tool for predicting IVF success in specific patient populations.