Related Experiment Video

Updated: Feb 14, 2026

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

1.0K

[Sudden Cardiac Death in Patients With Ischemic Heart Disease: From Mechanisms to Clinical Practice]

E Z Golukhova1, O I Gromova1, N I Bulaeva1

  • 1Federal State Budgetary Institution, "A.N. Bakulev Science Center of Cardiovascular Surgery" of the RF Ministry of Health Care.

Kardiologiia
|February 22, 2018
PubMed

Insights

Sudden cardiac death (SCD) risk increases after myocardial infarction (MI). This review explores electrophysiological changes and new predictors beyond ejection fraction for preventing fatal arrhythmias in ischemic heart disease (IHD) patients.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Surgery

Background:

  • Ischemic heart disease (IHD) and acute coronary syndrome are leading causes of sudden cardiac death (SCD).
  • Patients with myocardial infarction (MI) face a significantly higher risk of SCD compared to the general population.
  • Current primary prevention strategies for SCD often rely on left ventricular ejection fraction (LVEF), but this single metric has limitations.

Purpose of the Study:

  • To review electrophysiological alterations during acute myocardial ischemia.
  • To examine mechanisms of myocardial electromechanical remodeling in the post-MI period.
  • To identify and analyze modern additional predictors of fatal arrhythmias beyond LVEF.

Main Methods:

  • Literature review focusing on electrophysiological changes during ischemia and post-MI remodeling.
  • Analysis of current data on arrhythmia substrates and triggers.
  • Evaluation of contemporary predictors for fatal arrhythmias in clinical practice.

Main Results:

  • Acute myocardial ischemia induces significant electrophysiological changes.
  • Myocardial remodeling in the remote period after MI contributes to arrhythmogenesis.
  • Reduced LVEF is a key indicator, but additional predictors are crucial for comprehensive risk assessment.

Conclusions:

  • Relying solely on LVEF for SCD primary prevention is insufficient.
  • Identifying novel predictors of fatal arrhythmias is essential for improving patient outcomes.
  • Further research into these predictors holds significant clinical and social importance.

Keywords:
acute myocardial ischemiaarrhythmogenic substrateimplantable cardioverter defibrillatorsudden cardiac deathventricular tachyarrhythmias

More Related Videos

Pre-clinical Model of Cardiac Donation after Circulatory Death06:26

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

8.4K
Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes05:06

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Published on: May 5, 2020

14.4K

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.5K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
680
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.3K
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
10.1K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.8K
Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
1.1K