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Ferrous iron transport in Streptococcus mutans.

S L Evans, J E Arceneaux, B R Byers

    Journal of Bacteriology
    |December 1, 1986
    PubMed
    Summary

    Streptococcus mutans transports iron, but only in its ferrous form. Glucose metabolism provides reductants essential for iron reduction before uptake, enhanced by conditions like anaerobiosis and sodium ascorbate.

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    Area of Science:

    • Microbiology
    • Biochemistry
    • Iron Metabolism

    Background:

    • Streptococcus mutans is a key bacterium in dental caries development.
    • Iron is an essential nutrient for bacterial growth, but its uptake mechanisms can vary.
    • Understanding iron transport in S. mutans is crucial for developing targeted interventions.

    Purpose of the Study:

    • To investigate the mechanism of radioiron (59FeCl3) uptake by Streptococcus mutans OMZ176.
    • To determine the preferred iron valence state (ferrous or ferric) for transport.
    • To identify factors influencing iron uptake, such as anaerobiosis and specific chemical agents.

    Main Methods:

    • Utilized radioiron (59FeCl3) to quantify iron uptake by S. mutans.
    • Incubated bacteria under various conditions: anaerobiosis, presence of sodium ascorbate, and phenazine methosulfate (PMS).
    • Monitored iron uptake over time to assess the effects of different treatments.

    Main Results:

    • Radioiron uptake was significantly increased by anaerobiosis, sodium ascorbate, and PMS.
    • A 10-minute lag phase was observed before PMS-induced stimulation of iron uptake.
    • Sodium ascorbate likely provided ferrous iron, while reduced PMS may have generated ferrous iron and depleted oxygen.

    Conclusions:

    • Streptococcus mutans transports iron exclusively in the ferrous (Fe2+) form.
    • Bacterial glucose metabolism supplies reductants necessary for reducing ferric iron to ferrous iron prior to transport.
    • Anaerobic conditions and specific reductants enhance ferrous iron uptake in S. mutans.

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