Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microglia: You'll Never Walk Alone!

Nàdia Villacampa1, Michael T Heneka2

  • 1Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud Straße 25, 53127 Bonn, Germany.

Immunity
|February 22, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States.

medRxiv : the preprint server for health sciences·2026
Same author

Landscape of copy number variants in Spanish people with dementia.

NPJ genomic medicine·2026
Same author

Neuroinflammation and neurodegeneration trigger a specific splice form of ribosomal protein S24.

Brain : a journal of neurology·2026
Same author

MOLT: multi-object and lineage tracking in 2D and 3D biomedical time-series imaging.

BMC bioinformatics·2026
Same author

Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model.

The Journal of clinical investigation·2026
Same author

Longitudinal Monitoring of Brain Volume Changes After COVID-19 Infection Using Artificial Intelligence-Based MRI Volumetry.

Diagnostics (Basel, Switzerland)·2025
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
See all related articles

Researchers identified and characterized leukocyte populations in the central nervous system (CNS). This study provides new insights into immune cell roles in aging and CNS diseases.

Area of Science:

  • Neuroimmunology
  • Immunology
  • Proteomics

Background:

  • Identifying and characterizing leukocyte populations within the central nervous system (CNS) is crucial for understanding its immune landscape.
  • Aging and central nervous system diseases significantly alter immune cell composition and function.

Purpose of the Study:

  • To develop and apply advanced techniques for comprehensive identification and characterization of leukocyte populations in the CNS.
  • To investigate how these immune cells differ in healthy, aged, and diseased CNS environments.

Main Methods:

  • Utilized high-dimensional single-cell proteomics.
  • Employed high-parametric mass cytometry.
  • Analyzed leukocyte populations in healthy, aged, and diseased CNS tissues.

Related Experiment Videos

Main Results:

  • Successfully identified distinct resident and recruited leukocyte populations within the CNS.
  • Characterized the heterogeneity of these immune cells across different physiological and pathological states.
  • Provided a detailed molecular profile of CNS-resident and recruited leukocytes.

Conclusions:

  • The study offers a high-resolution view of the CNS immune landscape.
  • Findings contribute to a better understanding of immune cell involvement in CNS aging and disease.
  • This work establishes a foundation for future research into targeted immunotherapies for neurological disorders.