Related Experiment Video
Updated: Feb 14, 2026
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
8.1K
Screening for cognitive impairment in SLE using the Self-Administered Gerocognitive Exam.
A Meara1, N Davidson2, H Steigelman1
12 The Ohio State University Department of Internal Medicine, Division of Rheumatology Immunology, Columbus, OH, USA.
Lupus
|February 23, 2018
Summary
The Self-Administered Gerocognitive Exam (SAGE) can screen for cognitive impairment in Systemic Lupus Erythematosus (SLE) patients. Cognitive impairment in SLE is linked to lupus disease damage and lower income.
Area of Science:
- Neurology
- Rheumatology
- Psychology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs.
- Central nervous system involvement in SLE can lead to cognitive dysfunction, posing diagnostic challenges.
- Existing diagnostic methods for cognitive impairment in SLE are often time-consuming and costly.
Purpose of the Study:
- To evaluate the Self-Administered Gerocognitive Exam (SAGE) as a feasible screening tool for cognitive impairment in SLE patients.
- To identify factors associated with cognitive impairment in this cohort.
Main Methods:
- 118 SLE patients completed the SAGE cognitive screening tool.
- Disease activity and damage were assessed using SLEDAI and SLICC-DI.
- Statistical analyses, including univariate and multivariate models, were employed.
Main Results:
- 18% of SLE patients scored ≤16 on the SAGE, indicating cognitive impairment.
- Abnormal SAGE scores were significantly associated with higher SLICC-DI scores (lupus-related damage).
- Hispanic ethnicity and lower household income were also independently associated with abnormal SAGE scores.
Conclusions:
- The SAGE is a feasible tool for screening cognitive impairment in SLE patients within a clinical setting.
- Neurocognitive impairment in SLE is linked to cumulative disease damage and socioeconomic factors.
- Further research is needed to address potential language barriers impacting SAGE results in diverse populations.
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