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Sarcoidosis mortality in Sweden: a population-based cohort study
Marios Rossides1, Susanna Kullberg2,3,4, Johan Askling5,6
1Clinical Epidemiology Unit, Dept of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden marios.rossides@ki.se.
The European Respiratory Journal
|February 23, 2018
Summary
Individuals with sarcoidosis face a higher mortality risk. Those requiring treatment near diagnosis have a doubled risk, highlighting a vulnerable group for future interventions.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Public Health
Background:
- Sarcoidosis is a multisystem inflammatory disease with variable prognosis.
- Understanding sarcoidosis-related mortality is crucial for patient management and public health.
- Disease heterogeneity may influence mortality risk within the sarcoidosis population.
Purpose of the Study:
- To investigate mortality rates in a large, population-based cohort of sarcoidosis patients.
- To analyze mortality risk considering disease heterogeneity and treatment status.
- To identify subgroups of sarcoidosis patients at higher risk of death.
Main Methods:
- Utilized the Swedish National Patient Register to identify 8207 incident sarcoidosis cases (2003-2013).
- Matched 1:10 with non-sarcoidosis comparators based on birth year, sex, and county.
- Analyzed all-cause mortality using the Cause of Death Register, stratifying by age, sex, and treatment status.
Main Results:
- Sarcoidosis patients had a higher mortality rate (11.0 per 1000 person-years) versus comparators (6.7 per 1000 person-years).
- Overall hazard ratio for death in sarcoidosis was 1.61, with no significant variation by age or sex.
- Patients receiving treatment around diagnosis showed a significantly higher hazard ratio for death (2.34) compared to those not treated (1.13).
Conclusions:
- Sarcoidosis is associated with an increased risk of death compared to the general population.
- The elevated mortality risk is generally small for most sarcoidosis patients.
- Patients requiring treatment early in their disease course represent a vulnerable group with a substantially higher mortality risk, warranting focused interventions.
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