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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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Right Ventricular Dysfunction and Its Contribution to Morbidity and Mortality in Left Ventricular Heart Failure
Amresh Raina1,2, Talha Meeran3
1Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA, USA. amresh.raina@ahn.org.
Current Heart Failure Reports
|February 23, 2018
Summary
Right ventricular dysfunction significantly impacts symptoms and survival in left-sided heart failure (HF). More research is needed for targeted therapies to improve outcomes for these patients.
Area of Science:
- Cardiology
- Heart Failure Pathophysiology
Background:
- Left-sided heart failure (HF) traditionally focuses on left ventricular (LV) abnormalities.
- The role of right ventricular (RV) dysfunction in left-sided HF has been underemphasized.
- RV dysfunction contributes significantly to patient symptoms and prognosis.
Purpose of the Study:
- To highlight the importance of RV dysfunction in left-sided HF.
- To review the contribution of RV dysfunction to symptomatic limitations and cardiovascular outcomes.
- To emphasize the need for targeted RV therapies.
Main Methods:
- Literature review of recent studies on RV dysfunction in HF.
- Analysis of associations between RV dysfunction and HF subtypes (HFpEF, HFrEF).
- Examination of factors contributing to RV dysfunction and its impact on survival.
Main Results:
- RV dysfunction is prevalent in both HFpEF and HFrEF, more so in HFrEF.
- LV dysfunction and atrial fibrillation are common comorbidities with RV dysfunction.
- RV dysfunction is linked to functional decline and reduced survival in left-sided HF.
- RV failure is a leading cause of mortality in HFpEF.
- RV dysfunction impacts survival in LVAD and post-transplant patients.
Conclusions:
- RV dysfunction is a critical factor influencing symptoms and outcomes in left-sided HF.
- Current therapies do not specifically target RV dysfunction in this population.
- Development of pharmacotherapy targeting the RV is essential for improving patient care.
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