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Updated: Aug 10, 2026
10:42
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
[Keratoderma with epidermolytic hyperkeratosis]
Medicina Cutanea Ibero-Latino-Americana
|January 1, 1986
Summary
This study reports a family with Thost-Unna keratoderma and epidermolytic hyperkeratosis. Treatment with oral aromatic retinoids improved skin but caused erosions, necessitating discontinuation.
Area of Science:
- Dermatology
- Genetics
- Histopathology
Background:
- Thost-Unna keratoderma is a rare inherited skin disorder.
- Epidermolytic hyperkeratosis is a condition characterized by abnormal keratinization.
- The association between these two conditions is not fully understood.
Observation:
- Three family members presented with Thost-Unna keratoderma and epidermolytic hyperkeratosis.
- Literature review included cases of keratoderma with similar histopathological findings.
- Treatment with oral aromatic retinoids initially improved hyperkeratosis.
Findings:
- Aromatic retinoid treatment led to skin erosions and discomfort, requiring discontinuation.
- The study highlights the potential for adverse effects even with improved hyperkeratosis.
- Histopathological examination is crucial for accurate diagnosis.
Implications:
- Increased recognition of the association between keratoderma and epidermolytic hyperkeratosis is needed.
- Careful monitoring is essential during retinoid therapy for such conditions.
- Further research may elucidate optimal treatment strategies for this specific dermatosis.
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