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Published on: May 27, 2011
Eccrine squamous syringometaplasia in an allogenic stem cell transplant patient undergoing chemotherapy
Kevin Nethers1, Jane Messina, Lucia Seminario-Vidal
1University of South Florida, Department of Dermatology and Cutaneous Surgery, Tampa, Florida.
Abstract:
Eccrine squamous syringometaplasia (ESS) is a rare finding defined as metaplastic change of the cuboidal epithelial cells of eccrine glands into two or more layers of squamous epithelial cells. We present a patient who developed ESS after induction of CLAG chemotherapy [2-Chlorodeoxyadenosine (2-CdA) with cytarabine (Ara-C) and (granulocyte-colony stimulating factor) G-CSF] for management of the blast crisis of his chronic myelogenous leukemia (CML). Our patient's ESS eruption presented with a variety of morphologies, thus multiple skin biopsies were taken to determine the possible diagnosis(es). All skin biopsies showed ESS and the eruption resolved with topical corticosteroids after CLAG therapy was finished.
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