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Telangiectasia macularis eruptiva perstans associated with a sicca complex
Ramone Faith Williams1, Rosalynn M Nazarian, Gideon P Smith
1Division of Dermatology, Albert Einstein School of Medicine, Montefiore Medical Center. ramone.f.williams@gmail.com.
Dermatology Online Journal
|February 23, 2018
Summary
A woman developed telangiectasia macularis eruptiva perstans (TMEP) with dry eyes and mouth. Aberrant mast cells in her salivary gland suggest mastocytosis causes salivary compromise.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Telangiectasia macularis eruptiva perstans (TMEP) is a rare cutaneous condition.
- Mast cell disorders can affect multiple organ systems.
Observation:
- A woman in her 50s presented with TMEP, dry eyes, and dry mouth.
- Skin biopsy confirmed TMEP; elevated serum tryptase indicated systemic involvement.
- Salivary gland biopsy showed aberrant CD117-positive mast cell infiltrates.
Findings:
- The patient's symptoms and biopsy results suggest a link between TMEP and salivary gland dysfunction.
- Aberrant mast cell infiltration in salivary glands points to mastocytosis as a potential cause of dry mouth and eyes.
Implications:
- This case highlights a potential mechanism for salivary compromise in mast cell-related disorders.
- Further research into mastocytosis's role in sicca symptoms is warranted.
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