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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Wound Management and Surgery for Calcific Uremic Arteriolopathy (Calciphylaxis): A Retrospective Observational Cohort
Scott J Moses1, Matthew Supple1, Houda Bouchouari2
1Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
International Wound Journal
|February 27, 2026
Summary
Surgical debridement and wound closure are safe and effective for calciphylaxis wounds. This multidisciplinary approach showed excellent healing rates without disease progression, improving patient outcomes in calciphylaxis wound care.
Area of Science:
- Dermatology
- Vascular Surgery
- Nephrology
Background:
- Calciphylaxis wound care lacks evidence-based guidelines for surgical intervention.
- Optimal timing and techniques for surgical management of calciphylaxis wounds are undefined.
Purpose of the Study:
- To evaluate the safety and efficacy of surgical debridement and wound closure in calciphylaxis.
- To describe a systematic, multidisciplinary approach to surgical intervention for calciphylaxis wounds.
Main Methods:
- Retrospective review of patients with calciphylaxis undergoing surgical debridement.
- Analysis focused on wound healing, amputation rates, and mortality.
- Categorization of wound closure methods: skin grafting, primary closure, and secondary intention.
Main Results:
- Sixty-two patients underwent surgical debridement for calciphylaxis.
- Excellent healing rates were observed across all closure groups (skin grafting, primary closure, secondary intention).
- No patients experienced wound progression or new lesions post-operatively.
Conclusions:
- Surgical debridement and wound closure are safe and effective treatments for calciphylaxis-related wounds.
- A multidisciplinary approach facilitates successful surgical management.
- This intervention improves wound healing outcomes in calciphylaxis patients.
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