Related Experiment Video
Updated: Jun 11, 2026

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
Published on: May 12, 2020
Calciphylaxis complicated by NDM-1-producing Pseudomonas aeruginosa: first experience with cefepime-zidebactam
Erlinda R Ulloa1, Daniel Jaffurs2, M Tuan Tran3
1Division of Infectious Diseases, Children's Hospital of Orange County, Orange, CA, USA; Department of Pediatrics, University of California Irvine School of Medicine, Irvine, CA, USA.
Abstract:
We report a case of calciphylaxis-a rare vasculopathy characterised by arteriolar calcification and ischaemic skin necrosis-in a young woman with acute myeloid leukaemia. Her ulcerated skin lesions became superinfected with a pan-resistant New Delhi metallo-β-lactamase-1-producing Pseudomonas aeruginosa. Although such infections in the USA have largely been associated with international travel, our patient harboured one of the earliest domestically acquired isolates. Management required novel therapeutic strategies, including the first use of cefepime-zidebactam in the USA alongside bacteriophage therapy and calciphylaxis-directed treatment. This case highlights the diagnostic complexity of calciphylaxis in atypical populations and shows the potential for innovative therapeutic approaches to achieve favourable outcomes in this rare, potentially fatal condition.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Inhibitors of Bacterial DNA Synthesis
Rocky Mountain Spotted Fever
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
