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GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

Marina Besprozvannaya1, Eamonn Dickson2, Hao Li3

  • 1Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States.

Elife
|February 23, 2018
PubMed
Summary

Human GRAMD proteins GRAMD1a and GRAMD2a are endoplasmic reticulum-plasma membrane contact site proteins. GRAMD2a organizes specialized ER-PM contact sites involved in calcium homeostasis and STIM1 recruitment.

Keywords:
ER-PM contact sitesGRAMD proteinsPIP lipidscell biologycortical ERhumanmembrane contact sitestore operated calcium entry

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