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Updated: Feb 14, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
The Central Effects of Androgenic-anabolic Steroid Use
Marek Mędraś1, Anna Brona, Paweł Jóźków
1Department of Endocrinology, Diabetology & Isotope Treatment, Wrocław Medical University, Wrocław, Poland (MM); and Department of Sports Medicine & Dietetics, University School of Physical Education, Wrocław, Poland (MM, AB, PJ).
Abstract:
: Millions of men use androgenic-anabolic steroids (AAS) to stimulate muscle growth and improve physical appearance. Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. Although most addictive substances improve mood immediately after administration, AAS exert less pronounced euphoric effects. Instead, they are primarily taken for the delayed gratification of increased muscle mass. Withdrawal from AAS may lead to a range of somatic and psychiatric symptoms, and, in many cases, comprehensive treatment supervised by an endocrinologist and a psychiatrist is required.
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