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Updated: Feb 14, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
Polystyrene microsphere and 5-fluorouracil release from custom-designed wound dressing films
Maryam Mobed-Miremadi1, Raki Komarla Nagendra2, Sujana Lakshmi Ramachandruni2
1Department of Biomedical, Chemical and Materials Engineering, San Jose State University, San Jose, CA, 95192-0082, USA. maryam.mobed-miremadi@sjsu.edu.
This study developed chitosan and alginate wound dressing films for drug delivery. Alginate films offered better elasticity and longer drug release, while chitosan films showed higher moisture absorption, enabling tunable drug release kinetics.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Wound healing requires advanced dressings capable of controlled therapeutic agent delivery.
- Chitosan and alginate are biocompatible polymers with potential for wound dressing applications.
- Encapsulation of hydrophobic drugs in wound dressings presents formulation challenges.
Purpose of the Study:
- To prepare and characterize chitosan and alginate films for hydrophobic drug encapsulation.
- To investigate the influence of propylene glycol and calcium chloride on film properties and drug release kinetics.
- To evaluate the suitability of these films for controlled release of 5-Fluorouracil.
Main Methods:
- Film preparation via casting/solvent evaporation method.
- Parametric study varying propylene glycol (chitosan) and calcium chloride (alginate) concentrations.
- Mechanical and chemical property assessment: thickness, elasticity, tensile strength, sorption.
- In-vitro drug release studies using microspheres and 5-Fluorouracil (5-FU).
- Atomic force microscopy for pore size analysis.
Main Results:
- Alginate films exhibited higher elasticity, thinner profiles, and longer drug release durations (81% release) compared to chitosan films (42% release).
- Chitosan films demonstrated superior moisture permeability and sorption, indicating higher hydrophilicity.
- No significant difference in tensile strength between alginate and chitosan films.
- Encapsulation of 5-FU in chitosan films resulted in immediate film disintegration (tB=0), unlike control films (tB=70 min).
- Film pore size measured at 430 nm ± 88 nm validated the drug release modulation hypothesis.
Conclusions:
- Chitosan and alginate films can be tailored for specific wound dressing applications by adjusting formulation parameters.
- Alginate films are suitable for applications requiring elasticity and extended release, while chitosan films are better for moisture management.
- The developed films demonstrate potential for controlled delivery of hydrophobic drugs like 5-FU, with tunable release profiles based on drug-to-microsphere size ratios.
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