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Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum
Published on: May 22, 2018
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Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer
Sreedev Puthur1, A N Anoopkumar1, Sharrel Rebello1
1Communicable Disease Research Laboratory, St. Joseph's College, Irinjalakuda, Thrissur, India.
Applied Biochemistry and Biotechnology
|February 25, 2018
Summary
Hypericum japonicum exhibits potent mosquitocidal and anticancer properties. This natural compound shows promise for controlling disease-carrying mosquitoes and fighting cancer, offering a dual-action approach.
Area of Science:
- Ethnobotany
- Toxicology
- Natural Product Chemistry
Background:
- Mosquito-borne diseases and cancer pose significant global health threats.
- Increasing insecticide resistance necessitates novel mosquito control strategies.
- Potential for mosquitoes to transmit cancerous cells or viruses highlights the need for dual-action agents.
Purpose of the Study:
- To screen and characterize Hypericum japonicum for combined mosquitocidal and anticancerous activities.
- To evaluate the larvicidal efficacy of H. japonicum extracts against Aedes aegypti.
- To assess the in vitro cytotoxicity of H. japonicum extracts against Daltons Lymphoma Ascites cells.
Main Methods:
- Screening of different solvent extracts of Hypericum japonicum.
- Larvicidal bioassays using fourth instar larvae of Aedes aegypti.
- In vitro cytotoxicity assays against Daltons Lymphoma Ascites (DLA) cells.
Main Results:
- Methanolic extracts of H. japonicum demonstrated significant larvicidal activity (LC50 7.37 ppm, LC90 11.59 ppm).
- H. japonicum extracts exhibited potent in vitro cytotoxicity against DLA cells (LC50 0.95 ppm, LC90 1.85 ppm).
- This study is the first to report the dual mosquitocidal and anticancerous properties of Hypericum japonicum.
Conclusions:
- Hypericum japonicum possesses significant mosquitocidal and anticancerous properties.
- This plant-derived agent offers a potential dual-action strategy against infectious diseases and cancer.
- Further research into bioactive compounds of H. japonicum is warranted for therapeutic development.
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