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Oncogene-induced regulation of microRNA expression: Implications for cancer initiation, progression and therapy

Athanasios R Paliouras1, Tiziana Monteverde1, Michela Garofalo1

  • 1Transcriptional Networks in Lung Cancer, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, M20 4GJ, Manchester, UK.

Cancer Letters
|February 25, 2018
PubMed

Insights

Oncogenic mutations drive cancer by altering microRNA expression, impacting tumor growth and spread. Understanding these microRNA-oncogene interactions is key for developing novel cancer therapeutics.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Malignant transformation is driven by oncogenic mutations affecting multiple signaling pathways.
  • MicroRNAs (miRNAs), small non-coding RNAs, negatively regulate gene expression and play crucial roles in oncogenic signaling.
  • Differential miRNA expression is a hallmark of cancer and fundamental to tumorigenesis.

Purpose of the Study:

  • To explore the intricate relationship between oncogenic mutations and microRNA expression.
  • To elucidate how these interactions influence tumor initiation, progression, and metastasis.
  • To highlight the therapeutic implications of targeting miRNA-oncogene crosstalk in cancer treatment.

Main Methods:

  • Review of existing literature on oncogene-miRNA interactions.
  • Analysis of specific case studies demonstrating miRNA regulation by oncogenes.
  • Examination of the functional impact of these interactions across different stages of cancer.

Main Results:

  • Specific examples of oncogenes regulating miRNAs and their downstream effects were identified.
  • The study highlights how these interactions contribute to tumor initiation and progression.
  • The role of miRNA dysregulation in metastasis and its therapeutic potential were discussed.

Conclusions:

  • The interplay between oncogenes and miRNAs is a critical determinant of cancer development and progression.
  • Targeting these specific interactions offers promising avenues for novel cancer therapies.
  • Further research into miRNA-oncogene axes can refine therapeutic strategies for various malignancies.
Keywords:
MiRNA therapeuticsMicroRNAMicroRNA regulationOncogene addictionTumour initiationTumour progression

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