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Related Experiment Video

Updated: Feb 14, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Genetics of migraine.

Verneri Anttila1, Maija Wessman2, Mikko Kallela3

  • 1Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston; and Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States.

Handbook of Clinical Neurology
|February 27, 2018
PubMed
Summary

Recent advances in migraine genetics have identified 47 common variant loci, significantly improving our understanding of migraine susceptibility. These findings pave the way for personalized treatments and insights into related neurological conditions.

Keywords:
GWASfamilial hemiplegic migrainegeneticsheritability analysismigraineneurology

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Area of Science:

  • Neurogenetics
  • Complex Trait Genetics

Background:

  • Migraine genetics has evolved from rare Mendelian forms to identifying numerous common variant loci.
  • Genomewide association studies (GWAS) have been pivotal in this advancement.

Purpose of the Study:

  • To summarize recent breakthroughs in common migraine genetics.
  • To highlight the implications of identified genetic loci for understanding migraine mechanisms and comorbidities.

Main Methods:

  • Large-scale genomewide association studies (GWAS) with increasing sample sizes.
  • In silico analyses of identified genetic loci (e.g., TRPM8, PRDM16, LRP1).
  • Heritability-based analyses and polygenic risk score calculations.

Main Results:

  • Identification of 47 common variant loci associated with migraine susceptibility.
  • Evidence for both vascular and neuronal mechanisms in migraine pathogenesis.
  • Demonstrated genetic links between migraine and other neuropsychiatric disorders like major depressive disorder and ADHD.

Conclusions:

  • Recent genetic discoveries provide robust evidence for quantifiable genetic factors in common migraine.
  • These findings offer new avenues for pharmacogenetics, understanding functional etiology, and comorbidity research.
  • The genetic architecture of migraine is becoming increasingly clear, revealing connections to other brain phenotypes.