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Granulocyte transfusions in the management of neutropenic fever: A pediatric perspective

Dilek Gurlek Gokcebay1, Sibel Akpinar Tekgunduz1

  • 1University of Health Sciences, Ankara Kecioren Training and Research Hospital, Department of Pediatric Hematology and Oncology, Turkey.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|February 27, 2018
PubMed

Insights

Granulocyte transfusions may help children with cancer chemotherapy-induced neutropenic fever and severe infections. This review examines the benefits and risks of this supportive therapy.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Infectious Diseases

Background:

  • Invasive bacterial and fungal infections are leading causes of death in children undergoing cancer chemotherapy.
  • Severe neutropenia, a low white blood cell count, increases infection risk.
  • Granulocyte transfusion therapy is a supportive measure for severe infections in neutropenic patients.

Purpose of the Study:

  • To review the potential benefits and risks of granulocyte transfusions in pediatric patients with neutropenic fever.
  • To evaluate the effectiveness of granulocyte transfusions in managing severe infections in immunocompromised children.

Main Methods:

  • Systematic review of existing literature.
  • Appraisal of retrospective and prospective observational studies on pediatric granulocyte transfusion therapy.
  • Analysis of data on clinical outcomes, benefits, and risks.

Main Results:

  • Granulocyte transfusions can increase neutrophil counts in recipients.
  • Evidence from observational studies is not conclusive regarding efficacy.
  • The therapy aims to enhance neutrophil accumulation at infection sites.

Conclusions:

  • Granulocyte transfusion is a potential supportive therapy for severe infections in pediatric neutropenic patients.
  • Further conclusive data is needed to establish definitive benefits and risks.
  • The review highlights the need for careful consideration in managing neutropenic fever.

Keywords:
ChildrenFebrile neutropeniaGranulocyte transfusionLeukapheresisNeutropeniaSevere infection

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