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Integrative omics for health and disease
Konrad J Karczewski1,2, Michael P Snyder3
1Massachusetts General Hospital, Boston, MA, USA.
Nature Reviews. Genetics
|February 27, 2018
Summary
Integrating multiple omics technologies provides a comprehensive view of disease. This approach enhances understanding, diagnosis, and treatment for various conditions, overcoming limitations of individual omics methods.
Area of Science:
- Biomedical Science
- Genomics
- Proteomics
- Metabolomics
- Transcriptomics
Background:
- Omics technologies offer molecular insights for personalized medicine.
- Individual omics approaches have limitations in capturing full disease complexity.
Purpose of the Study:
- To review the potential and utility of integrating diverse omics data.
- To explore applications in understanding, diagnosing, and treating human diseases.
Main Methods:
- Review of current literature on multi-omics data integration.
- Discussion of case studies across various disease types.
Main Results:
- Integrated omics provide a more holistic biological perspective.
- Examples demonstrate utility in rare/common diseases, cancer, and transplant biology.
Conclusions:
- Multi-omics integration is crucial for a comprehensive understanding of disease.
- Challenges to clinical implementation of integrative omics require further attention.
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