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Adherence to antimuscarinics in children with overactive bladder

Alexandra Fortin1, Valérie Morin1, Sophie Ramsay2

  • 1Department of Pediatrics, CHU de Québec - Université Laval, Québec, Québec.

Paediatrics & Child Health
|February 27, 2018
PubMed

Insights

Pediatric adherence to antimuscarinic medications for overactive bladder is higher than in adults but lower than self-reported rates. Questioning self-reported adherence is crucial for effective treatment adjustments.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Adherence Research

Background:

  • Overactive bladder (OAB) treatment in children often involves antimuscarinic agents.
  • Adherence to antimuscarinic therapy is a known challenge in adults, with limited data in pediatric populations.
  • Understanding pediatric adherence is vital for optimizing OAB management.

Purpose of the Study:

  • To evaluate the adherence rates of children to antimuscarinic medications for OAB.
  • To identify factors influencing medication adherence in pediatric patients.
  • To compare measured adherence with self-reported adherence.

Main Methods:

  • A cohort of children (5-18 years) on antimuscarinics for ≥6 months completed a questionnaire.
  • Pharmacist records were used to calculate medication possession ratio (MPR) at 1, 3, 6, and 12 months.
  • Good adherence was defined as MPR ≥ 80%.

Main Results:

  • Seventy-two children were included, with a mean age of 10.1 years.
  • Self-reported adherence was high (93%), but MPR ≥ 80% was observed in 36% (1 month), 57% (3 months), 64% (6 months), and 74% (12 months) prior to questionnaire.
  • Post-questionnaire, MPR improved to 53% (1 month), 65% (3 months), and 71% (6 months). No influencing factors were identified.

Conclusions:

  • Measured antimuscarinic adherence in children with OAB is higher than in adults but significantly lower than self-reported adherence.
  • High self-reported adherence may lead to inappropriate treatment adjustments; critical evaluation is necessary.
  • Strategies to enhance medication adherence are essential for improving treatment outcomes in pediatric OAB.
Abstract

Keywords:
AnticholinergicsChildOveractive bladderPatient adherence.

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