Related Experiment Video

Updated: Feb 14, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

5.6K

Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis

Susanta Pahari1, Gurpreet Kaur1, Shikha Negi1

  • 1Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.

Frontiers in Immunology
|February 27, 2018
PubMed

Insights

The mononuclear phagocyte system (MPS) fights Mycobacterium tuberculosis (Mtb). Strategies to boost MPS function could lead to new tuberculosis (TB) immunotherapeutics.

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • The mononuclear phagocyte system (MPS), comprising dendritic cells, monocytes, and macrophages, is crucial for immune homeostasis and pathogen defense.
  • Mycobacterium tuberculosis (Mtb) infects MPS cells, particularly macrophages, establishing a persistent infection that leads to tuberculosis (TB).
  • Understanding the host-pathogen interaction within the MPS is key to controlling TB.

Purpose of the Study:

  • To explore strategies for enhancing MPS function against Mtb.
  • To identify mechanisms by which Mtb suppresses host immunity.
  • To highlight potential immunotherapeutic approaches for TB.

Main Methods:

  • Review of current literature on MPS function in TB pathogenesis.
  • Analysis of molecular mechanisms underlying Mtb-MPS interactions.
  • Discussion of innate immunity molecules for bolstering MPS activity.

Main Results:

  • Mtb manipulates MPS cells, leading to disease progression when the pathogen predominates.
  • Host immune response is suppressed by Mtb's intricate mechanisms within macrophages.
  • Reinvigorating MPS function is critical for overcoming Mtb infection.

Conclusions:

  • Targeting MPS function offers a promising avenue for TB treatment.
  • Exploiting innate immunity molecules can enhance MPS to combat Mtb.
  • Future immunotherapeutics may be developed based on these strategies to treat TB.
Keywords:
dendritic cellimmunotherapyinfectionmacrophagemonocytemononuclear phagocyte systempattern recognition receptorstuberculosis

More Related Videos

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring08:47

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring

Published on: November 13, 2008

11.8K
Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay07:19

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay

Published on: October 18, 2016

10.1K

Related Concept Videos

Reinforcement01:23

Reinforcement

Positive and negative reinforcement are key concepts in operant conditioning, a learning process where the consequences of a behavior affect the likelihood of that behavior being repeated.
Positive reinforcement occurs when a behavior is followed by the presentation of a rewarding stimulus, increasing the frequency of that behavior. For example:
960
Transfer Function in Control Systems01:21

Transfer Function in Control Systems

The transfer function is a fundamental concept in the analysis and design of linear time-invariant (LTI) systems. It offers a concise way to understand how a system responds to different inputs in the frequency domain. It serves as a bridge between the time-domain differential equations that describe system dynamics and the frequency-domain representation that facilitates easier manipulation and analysis.
To derive the transfer function, consider a general nth-order linear time-invariant...
1.6K
Corrosion of Reinforcement01:27

Corrosion of Reinforcement

The corrosion of steel reinforcement within concrete is a process influenced by the material's inherent properties and external factors. The high pH level of around 13, provided by calcium hydroxide present in concrete, initially protects the steel reinforcement by promoting the formation of a passive iron oxide layer on its surface.
However, over time and under certain conditions like carbonation, chloride ingress, and cracking this protective state can be compromised. Steel has areas with...
592
Reinforcement Schedules01:24

Reinforcement Schedules

Positive reinforcement is a powerful method for teaching new behaviors to both animals and humans. B.F. Skinner demonstrated this with his experiments using rats in a Skinner box. When a rat pressed a lever, it received a food pellet. This immediate reward encouraged the rat to repeat the behavior. This method, where a reward follows every instance of the behavior, is known as continuous reinforcement. It is highly effective for establishing new behaviors quickly.
Once a behavior is learned,...
532
Reinforcements in Concrete01:25

Reinforcements in Concrete

Reinforced concrete is a composite material used extensively in construction, combining the compressive strength of concrete with the tensile strength of steel. This synergy is essential as concrete, while excellent at resisting compression, is weak under tension. Steel bars, or rebars, are embedded in the concrete to handle these tensile forces. The choice of steel is strategic; it shares a similar coefficient of thermal expansion with concrete, which ensures uniformity in response to...
486
Fiber Reinforced Concrete01:22

Fiber Reinforced Concrete

Fiber-reinforced concrete significantly enhances the structural and nonstructural properties of traditional concrete by incorporating fibers like steel, glass, and polymers. These fibers, varying from natural ones such as sisal and cellulose to manufactured ones like polypropylene and Kevlar, are mixed into hydraulic cement with aggregates. Steel fibers, often preferred for their robustness, contribute to improved ductility, toughness, and post-cracking performance. The concrete is classified...
432