Metallosurfactant-based surface modification of biomedical alloys for inhibiting BSA adsorption and microbial...

The long-term performance of biomedical devices is frequently limited by the adhesion of biomolecules, proteins and microorganisms, prompting the development of surface modification strategies to enhance their antimicrobial activity and biocorrosion resistance. In this study, we have utilized Mo based double chain metallosurfactant (bishexadecylpyridiniummolybdenum pentachloride) over two standard biomedical alloys (SS 316 L and Ti-6Al-4 V) for improving their biocompatibility. Herein, the influence of antibacterial metallosurfactant coating on bovine serum albumin (BSA) adsorption, corrosion rates and bacterial adhesion was evaluated. The surface characteristics of this amphiphilic coating were evaluated using Field Emission-Scanning Electron Microscopy, Energy-dispersive X-ray spectroscopy, Atomic Force Microscopy and contact angle goniometry. These analyses revealed a porous morphology and multifluid repellent nature, characterized by low surface free energy (⁓30 ± 1.04 mN/m) of coating. Electrochemical evaluation, UV-vis spectroscopy, and X-ray photoelectron spectroscopy demonstrated the capacity of coatings to reduce corrosion currents and inhibit BSA adsorption.