Conversion of Atrial Fibrillation to Sinus Rhythm During Coronary Intervention: Complex Interplay of Arrhythmic and

Munish Sharma1, Daniel A N Mascarenhas2,3, Bharat Kantharia4

  • 1Department of Internal Medicine, Easton Hospital, Easton, PA, USA.

Cardiology Research
|February 27, 2018
PubMed

Insights

Atrial fibrillation (AF) during acute coronary syndrome (ACS) complicates patient management. This case study observed spontaneous AF to sinus rhythm conversion during percutaneous coronary intervention for right coronary artery stenosis.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Interventional Cardiology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia that can occur with acute coronary syndrome (ACS).
  • The coexistence of AF and ACS presents significant challenges in patient management and impacts prognosis.
  • Understanding the interplay between cardiac ischemia and arrhythmias is crucial for improving patient outcomes.

Observation:

  • A 77-year-old male patient with critical ostial stenosis of the right coronary artery underwent percutaneous coronary intervention (PCI).
  • During the PCI procedure, spontaneous conversion from atrial fibrillation (AF) to sinus rhythm was observed.
  • This electrophysiological event occurred in the context of treating significant coronary artery disease.

Findings:

  • The spontaneous resolution of AF to sinus rhythm during PCI suggests a potential link between coronary reperfusion and atrial electrical stability.
  • The specific electrophysiological mechanisms underlying this conversion remain to be fully elucidated but may involve improved myocardial oxygenation or altered autonomic tone.
  • This observation highlights the dynamic relationship between coronary blood flow and cardiac rhythm.

Implications:

  • This case provides insights into the complex electrophysiological interactions between acute coronary syndromes and atrial arrhythmias.
  • Further research into the mechanisms of AF conversion during PCI could lead to novel therapeutic strategies for ACS patients with arrhythmias.
  • Understanding these phenomena may improve risk stratification and treatment protocols for patients presenting with both AF and ACS.

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.1K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K
Gene Conversion02:08

Gene Conversion

3.1K
Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.4K
Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
4.0K