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Updated: Feb 14, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Chirality in metal-based anticancer agents
Yi Wang1, Huaiyi Huang2, Qianling Zhang1
1College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, P. R. China. p.zhang6@szu.edu.cn.
Abstract:
Chiral natural biological molecules, such as nucleic acids and proteins, guide the research of chiral compounds. Chiral metal-based drugs are currently an interesting and rapidly growing field in anticancer research. This perspective focuses on chiral metal compounds with application in cancer chemotherapy. The different chiral metal-based anticancer agents and the extent to which the chiral resolution affects their biological properties are discussed. This perspective will aid the design of new potent and efficient chiral metal-based anticancer drugs that exploit their unique properties combined with their potential selectivity toward targeted chiral biomolecules.
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