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Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii
Hao-Wen Jiang1,2, Shan-Shan Gu3,4, Lei Cao3
1a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development , East China Normal University , Shanghai , People's Republic of China.
Abstract:
Three new acetophenones, named cynwilforones A-C (1-3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.
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