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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

32.7K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.2K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

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Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement.

Eleonora Napoli1, Trenton Lippert2, Cesar V Borlongan3

  • 1Department of Molecular Biosciences, University of California Davis, Davis, CA, USA. enapoli@ucdavis.edu.

Advances in Experimental Medicine and Biology
|February 27, 2018
PubMed
Summary
This summary is machine-generated.

Stem cells can be repurposed to catalyze brain repair. Instead of cell replacement, their intrinsic properties can stimulate the brain's natural healing mechanisms for regenerative medicine.

Keywords:
Cell transplantationEndogenous brain repairNeurogenic nichesNeurological disorders

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Developmental Biology

Background:

  • Stem cells possess naive cellular features and potential for tissue differentiation.
  • Transplantable stem cells offer promise for treating age-related and injury-related diseases.
  • Human neural stem cells can enhance endogenous repair in the brain.

Purpose of the Study:

  • To explore the therapeutic potential of stem cells beyond cell replacement.
  • To investigate stem cells as catalysts for brain regeneration.
  • To understand the role of stem cells in neurogenic niches.

Main Methods:

  • Review of recent laboratory evidence on transplanted neural stem cells.
  • Analysis of regenerative molecules within brain neurogenic areas.
  • Conceptual advancement of stem cell therapeutic repurposing.

Main Results:

  • Transplanted human neural stem cells facilitate endogenous reparative mechanisms.
  • Brain neurogenic niches contain potent regenerative molecules (cytokines, proteomes, neurotrophic factors).
  • These molecules form a biochemical cocktail crucial for brain function restoration.

Conclusions:

  • Stem cells can be therapeutically repurposed as regenerative catalysts in the brain.
  • Exploiting intrinsic stem cell properties offers a novel approach to brain repair.
  • This strategy moves beyond traditional cell replacement for neurodegenerative diseases.