Topical Nystatin Treatment for Candida Infection Following Wound Reconstruction

Wound infection is an important cause of nonhealing wounds and graft rejection.

A series of 5 patients (4 females, 1 male; median age, 50; age range, 1.5-83 years) with nosocomial Candida infection of burns and chronic wounds that were reconstructed with split-thickness skin grafts is presented.

This case series was carried out between February 2011 and June 2014. Based on tissue cultures, wounds were treated with 100 000 units/mL of nystatin and 25 mg in 500 cc normal saline of mafenide acetate, which resulted in regression of wound infection symptoms and improvement of skin graft take.

The authors propose this simple, nontoxic, and economic topical treatment for wounds and skin grafts with positive Candida cultures.