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Electrocardiographic changes in children with diabetic ketoacidosis and ketosis

Deniz Aygün1, Fatih Aygün1, Kemal Nişli2

  • 1Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey.

Turk Pediatri Arsivi
|February 28, 2018
PubMed

Insights

Electrocardiography in children with diabetic ketoacidosis and ketosis revealed QTc length prolongation. This finding was linked to ketosis, not electrolyte levels, highlighting ECG

Area of Science:

  • Pediatric Cardiology
  • Endocrinology
  • Clinical Electrophysiology

Background:

  • Diabetic ketoacidosis (DKA) and ketosis are serious complications of diabetes in children.
  • Electrocardiographic (ECG) changes can occur in metabolic disturbances.
  • The relationship between ECG parameters and ketosis severity in pediatric DKA requires further investigation.

Purpose of the Study:

  • To investigate electrocardiographic (ECG) changes in children diagnosed with diabetic ketoacidosis (DKA) and ketosis.
  • To determine the correlation between ECG alterations, serum electrolyte levels, and the degree of ketosis.
  • To assess the clinical significance of ECG monitoring in pediatric DKA and ketosis.

Main Methods:

  • Prospective evaluation of ECG parameters, including QTc length, in pediatric patients with DKA and ketosis.
  • ECG assessments were performed at the time of diagnosis and post-treatment.
  • Analysis of the correlation between ECG findings, serum electrolytes, and anion gap.

Main Results:

  • QTc length prolongation was observed in pediatric patients with DKA and ketosis.
  • The mean QTc length significantly decreased after treatment.
  • Prolongation of QTc length was statistically correlated with the anion gap, but not with serum electrolyte levels.

Conclusions:

  • QTc length prolongation is a significant electrocardiographic finding in children with DKA and ketosis.
  • Performing electrocardiography is important for diagnosing and managing pediatric DKA and ketosis.
  • Ketosis, rather than electrolyte disturbances, appears to be the primary driver of QTc prolongation in this population.
Abstract

Keywords:
Diabetic ketoacidosisQTc lengthelectrocardiographyketosis

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