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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Cellular Stress Associated with Aneuploidy.

Jin Zhu1, Hung-Ji Tsai1, Molly R Gordon1

  • 1Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Developmental Cell
|February 28, 2018
PubMed
Summary

Aneuploidy, an abnormal chromosome number, causes cellular stress including proteotoxic, metabolic, and mitotic issues. This review explores how aneuploidy-induced stress impacts immune surveillance against cancer cells.

Keywords:
aneuploidymetabolic stressmitotic stressproteotoxic stressreplication stress

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Area of Science:

  • Genetics and Molecular Biology
  • Cell Biology
  • Cancer Biology

Background:

  • Aneuploidy, a deviation from the normal chromosome number, is prevalent in microbes, human tissues, and most solid tumors.
  • It arises from errors in chromosome segregation during cell division.
  • Aneuploid cells exhibit an imbalance in gene dosage, affecting cellular functions.

Purpose of the Study:

  • To review the cellular stress states induced by aneuploidy.
  • To assess the impact of gene dosage imbalance on proteotoxic, metabolic, replication, and mitotic stress.
  • To highlight the downstream effects of aneuploidy-induced stress on immune surveillance.

Main Methods:

  • Literature review of current research on aneuploidy and cellular stress.
  • Analysis of gene dosage imbalance in aneuploid cells.
  • Examination of emerging findings on immune surveillance against aneuploid cells.

Main Results:

  • Aneuploidy triggers significant cellular stress, including proteotoxic, metabolic, replication, and mitotic stress.
  • Gene dosage imbalance is a key driver of these stress responses.
  • Aneuploidy-induced cellular stress influences the immune system's ability to detect and eliminate aneuploid cells.

Conclusions:

  • Aneuploidy is a significant source of cellular stress with broad implications.
  • Understanding these stress pathways is crucial for developing cancer therapies.
  • Aneuploidy-induced stress impacts immune surveillance, offering potential therapeutic targets.